Solid sample loading is a useful technique to load samples to be purified with a CombiFlash® instrument onto a RediSep® Rf column, particularly in the case of low-solubility samples. All CombiFlash systems are designed for either solid or liquid sample loading.
Teledyne Isco Solid Phase Sample Load Cartridges are available either empty (to fill with your own sorbent) or pre-filled with silica gel or reversed-phase C18 material. Several sizes of sample load cartridges (5, 25, 65, and 270 gram nominal sorbent capacity) allow loading of sample amounts from milligrams to tens of grams.
When used on the CombiFlash Companion® and Rf systems, the cartridges are used with a solid load cartridge cap. This adjustable cap minimizes void volumes in the cartridge so that accurate gradients can be delivered.